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目的:探讨P-选择素、血小板激活因子(PAF)水平变化在急性心肌梗死的意义。方法:用ELISA法测定30例急性心肌梗死(AMI)及对照组20例隐匿性冠心病(LCHD)患者的P-选择素、PAF水平,同时测定末梢血WBC计数、N%及心肌酶谱。结果:AMI患者的可溶性P-选择素、PAF明显增高。可溶性P-选择素,PAF与末梢血WBC计数,N%、心肌酶谱及AMI的面积呈正相关。结论:可溶性P-选择素,PAF在AMI患者明显增高,与炎性反应有关。
Objective: To investigate the significance of P-selectin and platelet activating factor (PAF) levels in acute myocardial infarction. Methods: P-selectin and PAF levels in 30 patients with acute myocardial infarction (AMI) and 20 patients with occult coronary heart disease (LCHD) were measured by ELISA. WBC counts, N% and myocardial enzymes were also determined. Results: The soluble P-selectin and PAF were significantly higher in AMI patients. Soluble P-selectin, PAF and peripheral blood WBC count, N%, myocardial enzymes and AMI area was positively correlated. Conclusion: Soluble P-selectin and PAF are significantly elevated in patients with AMI, which is related to inflammatory reaction.