1例89岁女性患者因抑郁症服用艾司西酞普兰10 mg、1次/d。3个月后患者因突发头晕、跌倒入院。入院后继续服用艾司西酞普兰。入院第6天患者再次发生晕厥，心电监护监测到一过性室性心动过速，心电图检查示心率校正后QT间期（QTc）612 ms。停用艾司西酞普兰。次日患者再次发生室性心动过速，心电图检查示尖端扭转型室性心动过速，QTc 727 ms，血钾2.84 mmol/L，给予静脉及口服补钾治疗。入院第9天患者血钾和心电图恢复正常，QTc 487 ms。再次加用艾司西酞普兰（剂量同前）。随后5 d，心电图检查示QTc逐渐延长至506 ms，但血钾正常。再次停用艾司西酞普兰，2 d后QTc降至495 ms。停药27 d后心电图检查示QTc 467 ms。“,”An 89-year-old female patient received escitalopram 10 mg once daily for depression. Three months later, the patient was admitted to hospital for sudden dizziness and a fall. Escitalopram was continued after the admission. On the 6th day of admission, the patient developed syncope again, transient ventricular tachycardia was found by electrocardiogram (ECG) monitoring, and the ECG showed the rate-corrected QT interval (QTc) 612 ms. Escitalopram was discontinued. However, the next day the patient developed ventricular tachycardia again, and the ECG showed Torsades de Pointes and QTc 727 ms. The serum potassium level was 2.84 mmol/L and the patient was given intravenous and oral potassium supplementation. On the 9th day of admission, the patient′s serum potassium level and ECG returned to normal, and the QTc was 487 ms. Escitalopram (with the same dose as before) was given again. The next 5 days, her QTc gradually extended to 506 ms, but serum potassium was normal. Escitalopram was discontinued again and the QTc shortened to 495 ms 2 days later. After 27 days of drug withdrawal, the ECG showed the QTc was 467 ms.