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目的：探讨内皮素在急性排异反应移植肾内分布和特征。方法：用病理、免疫组化和定量分析的方法，对４８例急性排异肾和８例正常肾进行病理与内皮素分布及相对含量测定。结果：内皮素分布与病理改变基本一致，急性管型坏死组是以肾小管为主，间质排异组是以血管内皮损害为主，而血管排异组则是以肾小球的损害为特征性分布。内皮素的相对含量表明，病变组与正常组相比较有显著差异（Ｐ＜０．０５或Ｐ＜０．０１）。管型坏死组与血管排异组的含量相比较差异显著（Ｐ＜０．０５或Ｐ＜０．０１），间质排异组和血管排异组的相对含量相比较有显著差异（Ｐ＜０．０５或Ｐ＜０．０１）。结论：在肾移植排异反应时，通过测定内皮素的含量变化，指导应用拮抗剂进行治疗具有重要意义。
Objective: To investigate the distribution and characteristics of endothelin in the kidney after acute rejection. Methods: Pathological, immunohistochemical and quantitative analysis of 48 cases of acute rejection kidney and 8 cases of normal kidney pathological and endothelin distribution and relative content determination. Results: Endothelin distribution and pathological changes were basically the same, the acute tubular necrosis group is the main tubular, interstitial rejection group is the main vascular endothelial damage, vascular rejection group is the glomerular damage is Characteristic distribution. The relative content of endothelin showed that there was a significant difference between the lesion group and the normal group (P <0.05 or P <0.01). There was significant difference between the group of vascular necrosis and the group of vascular exclusion (P <0.05 or P <0.01), and the relative content of interstitial and vascular rejection was significantly different (P < 0.05 or P <0.01). CONCLUSION: It is of great significance to guide the application of the antagonist in the treatment of renal transplant rejection by measuring the change of endothelin content.