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目的 :探讨蒙脱石散对盐酸左氧氟沙星体外吸附的影响。方法 :采用不同剂量的盐酸左氧氟沙星分别与 3g蒙脱石散混合 ,加入 0 .1mol·L-1盐酸溶液中 ,在 (37± 0 .5 )℃水浴中恒温 2h后过滤 ,用紫外分光光度法测定盐酸左氧氟沙星的含量变化。结果 :蒙脱石散对盐酸左氧氟沙星的吸附率为 (98.37± 0 .0 3) %。结论 :蒙脱石散对盐酸左氧氟沙星有极强吸附 ,因此应避免两种药物同时服用
Objective: To investigate the effect of montmorillonite powder on levofloxacin hydrochloride adsorption in vitro. Methods: Different dosages of levofloxacin hydrochloride were mixed with 3g montmorillonite powder respectively, then added with 0.1mol·L-1 hydrochloric acid solution and heated at 37 ± 0. 5 ℃ for 2h, then filtered by UV spectrophotometry Determination of levofloxacin hydrochloride content changes. Results: The adsorption rate of montmorillonite to levofloxacin hydrochloride was (98.37 ± 0.30)%. Conclusion: Montmorillonite powder has a strong adsorption of levofloxacin hydrochloride, it should avoid taking the two drugs at the same time