目的:分析剪切波速度（SWV）联合促甲状腺激素（TSH）在甲状腺功能亢进症（甲亢）诊断中的应用价值。方法:选择安徽医科大学附属阜阳医院2017年12月至2019年9月诊治的甲亢患者35例（甲亢组），同时选择30例门诊正常健康体检者（对照组），两组入选者均予以常规二维超声及SWV检查，比较两组SWV及血清TSH、促甲状腺素受体抗体（TRAb）、甲状腺球蛋白抗体（TGAb）、甲状腺过氧化物酶抗体（TPOAb）表达水平，采用Pearson相关分析法对甲亢患者SWV值与血清TSH、TRAb、TGAb、TPOAb表达水平的相关性进行分析，采用受试者工作特征（ROC）曲线分析单一SWV值、血清TSH检测及联合SWV值和TSH检测诊断甲亢的价值。结果:甲亢组患者不同部位SWV值比较差异无统计学意义（n P>0.05），甲亢组患者甲状腺左、右叶的上极、中极、下极SWV值均明显高于对照组相同部位SWV值[左叶：（2.41 ± 0.34）m/s比（2.07 ± 0.28）m/s、（2.44 ± 0.39）m/s比（2.08 ± 0.25）m/s、（2.46 ± 0.43）m/s比（2.04 ± 0.30）m/s；右叶：（2.47 ± 0.42）m/s比（2.01 ± 0.25）m/s、（2.41 ± 0.40）m/s比（1.95 ± 0.23）m/s、（2.43 ± 0.35）m/s比（2.06 ± 0.24）m/s]（n P<0.01）；甲亢组患者血清TSH水平低于对照组[（0.05 ± 0.03）kU/L比（2.74 ± 1.17）kU/L]，而血清TRAb、TGAb、TPOAb水明显高于对照组[（15.82 ± 5.54）U/L比（0.55 ± 0.13）U/L、（290.63 ± 145.03）kU/L比（25.63 ± 7.12）kU/L、（627.17 ± 250.33）kU/L比（34.32 ± 5.95）kU/L]，差异均有统计学意义（n P<0.01）；甲亢组患者SWV值与血清TSH呈负相关（n r=- 0.862，n P<0.05），而与血清TRAb、TGAb、TPOAb呈正相关（n r=0.763、0.837、0.804，n P0.05). The SWV values of upper hole, middle pole and lower pole of the left and right lobe of thyroid in the hyperthyroidism group were significantly higher than those in the control group [left lobe: (2.41 ± 0.34) m/s vs. (2.07 ± 0.28) m/s, (2.44 ± 0.39) m/s vs. (2.08 ± 0.25) m/s, (2.46 ± 0.43) m/s vs. (2.04 ± 0.30) m/s; right lobe: (2.47 ± 0.42) m/s vs.(2.01 ± 0.25) m/s, (2.41 ± 0.40) m/s vs. (1.95 ± 0.23) m/s, (2.43 ± 0.35) m/s vs. (2.06 ± 0.24) m/s] (n P<0.01). The serum TSH level in the hyperthyroidism group were significantly lower than that in the control group [(0.05 ± 0.03) kU/L vs. (2.74 ± 1.17) kU/L], while serum TRAb, TGAb and TPOAb levels were significantly higher than those in the control group [(15.82 ± 5.54) U/L vs. (0.55 ± 0.13) U/L, (290.63 ± 145.03) kU/L vs. (25.63 ± 7.12) kU/L, (627.17 ± 250.33) kU/L vs. (34.32 ± 5.95) kU/L], and the differences were statistically significant (n P<0.01). In the hyperthyroidism group, the SWV was negatively correlated with serum TSH (n r=- 0.862, n P<0.05), but positively correlated with serum TRAb, TGAb and TPOAb (n r=0.763, 0.837, 0.804, n P<0.05). The area under curve(AUC), sensitivity and specificity of combined diagnosis of hyperthyroidism with SWV value and serum TSH were 0.936, 94.29% and 91.43%, which was better than that of SWV (0.803, 80.00%, 74.29%) and serum TSH (0.842, 82.86%, 77.14%).n Conclusions:SWV combined with TSH has a high clinical value in the diagnosis of hyperthyroidism.