论文部分内容阅读
选用4周龄SD大鼠,经口染毒高硒(5.68mg/kg)、富硒(0.73mg/kg)和(或)高镉(33.3mg/kg)12周,并分别在实验的第3、6、9、12周末各处死一批大鼠,研究经口摄入高硒高镉对大鼠肝、肾组织中镉、锌、铜含量的影响。结果表明:同时摄入高硒高镉组大鼠体内镉蓄积明显低于单纯摄入高镉组;对单独摄入高硒、高镉所诱导的大鼠肝脏锌含量增加表现为拮抗作用;对单独摄入高硒所致大鼠肾脏锌含量降低的影响表现为拮抗作用;对单独摄入高硒、高镉所致大鼠肾脏铜含量增加的影响表现为协同作用。
The 4-week-old SD rats were selected and orally administered with high selenium (5.68mg / kg), Se (0.73mg / kg) and / or high cadmium (33.3mg / kg) for 12 weeks. At the end of the 3rd, 6th, 9th and 12th week, a series of rats were sacrificed to study the effect of high intake of Se and Cd on the contents of Cd, Zn and Cu in the liver and kidney of rats. The results showed that the accumulation of cadmium in rats with high selenium and high cadmium at the same time was significantly lower than that of the high-cadmium group alone, and the antagonism of zinc content in the liver induced by high-selenium and high cadmium alone was not significant. The effect of single intake of high-selenium-induced zinc deficiency in rat kidney was antagonistic. The synergistic effect on the increase of copper content in rats with high selenium and high cadmium alone was observed.