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目的:观察中西医结合疗法治疗晚期大肠癌的临床疗效。方法:将42例患者随机分为2组各21例,对照组接受单纯XELOX化疗方案治疗,治疗组在对照组化疗基础上加用健脾益气,解毒散结中药治疗。观察临床疗效和毒副反应情况。结果:中医症状疗效总有效率治疗组为90.48%,对照组为57.14%,2组比较,差异有显著性意义(P<0.05);肿瘤近期疗效总有效率治疗组为38.09%,对照组为14.28%,2组比较,差异有显著性意义(P<0.05);治疗组恶心呕吐、贫血、食欲不振及白细胞减少发生率明显低于对照组,2组比较,差异均有显著性意义(P<0.05);2组外周神经毒性发生率相仿,差异无显著性意义(P>0.05)。治疗后治疗组卡氏评分以及生活质量评分改善显著优于对照组,2组比较,差异有显著性意义(P<0.05);治疗组治疗后骨髓抑制情况轻于对照组,2组比较,差异有显著性意义(P<0.05);2级肝损伤情况相仿,差异无显著性意义(P>0.05)。治疗组治疗后CEA显著下降,2组比较,差异有显著性意义(P<0.05);2组治疗后体重差异无显著性意义(P>0.05)。结论:中西医结合疗法治疗晚期大肠癌疗效显著,可提高有效率、降低不良反应。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of advanced colorectal cancer. Methods: Forty-two patients were randomly divided into two groups (n = 21 in each group). The control group received simple XELOX chemotherapy. The treatment group was treated with Jianpi Yiqi and Jiedu Sanjie Chinese herbs in the control group. To observe the clinical efficacy and toxicity. Results: The total effective rate of TCM symptoms was 90.48% in the treatment group and 57.14% in the control group. There was significant difference between the two groups (P <0.05). The total effective rate of the treatment group was 38.09% (P <0.05). The incidences of nausea, vomiting, anemia, loss of appetite and leukopenia in the treatment group were significantly lower than those in the control group (P <0.05). There was significant difference between the two groups <0.05). There was no significant difference in the incidence of peripheral neurotoxicity between the two groups (P> 0.05). After treatment, the treatment group, the Chi score and quality of life improved significantly better than the control group, the two groups, the difference was significant (P <0.05); bone marrow suppression after treatment was lighter than the control group, the two groups, the difference (P <0.05). Grade 2 liver injury was similar, with no significant difference (P> 0.05). After treatment, CEA was significantly decreased in the treatment group. There was significant difference between the two groups (P <0.05). There was no significant difference in weight between the two groups after treatment (P> 0.05). Conclusion: Integrative treatment of advanced colorectal cancer with significant effect, can improve the efficiency and reduce adverse reactions.