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为探讨采用快速固相免疫层析法测定心肌肌钙蛋白Ⅰ(cTnI)和选择性免疫抑制紫外法测定肌酸激酶同工酶(CK-MB)及在急性心肌梗死(AMI)诊断中的价值,本文分别对52例AMI患者于胸痛发生后4、8、12、24、48h及第5、7d和26名正常对照者的血清进行了cTnI及CK-MB的测定。结果表明,AMI组血清cTnI、CK-MB的测定值均明显高于正常对照组,具有显著性差异(P<0.01);AMI患者cTnI在4h及第5、7d时的阳性率均明显高于CK-MB,具有显著性差异(P<0.01)。以上数据表明,cTnI在诊断急性心梗中具有较高的灵敏度及高度特异性,尤其是采用快速固相免疫层析法检测cTnI,可为快速诊断AMI提供依据,具有临床应用价值。
To investigate the value of rapid solid phase immunochromatographic assay for the determination of cardiac troponin Ⅰ (cTnI) and selective immunosuppressive ultraviolet (CK-MB) in the diagnosis of acute myocardial infarction (AMI) In this paper, cTnI and CK-MB were measured in serum of 52 patients with AMI at 4, 8, 12, 24, 48h and 5, 7d and 26 normal controls respectively. The results showed that the serum levels of cTnI and CK-MB in AMI group were significantly higher than those in normal control group (P <0.01). The positive rates of cTnI in AMI patients at 4h and 5th and 7th day were significantly higher than those in AMI group CK-MB, with significant difference (P <0.01). The above data show that, cTnI in the diagnosis of acute myocardial infarction with high sensitivity and high specificity, especially the rapid solid phase immunochromatographic detection of cTnI, can provide a basis for rapid diagnosis of AMI, with clinical value.