论文部分内容阅读
目的:探讨C反应蛋白(C-reactive portein,CRP)基因C+1444T多态性与急性冠脉综合征(acute coronary syndrome,ACS)的易感性。方法:选择2003年11月～2008年5月住院的ACS患者443例(ACS组)和同期经冠脉造影排除冠心病者285例(对照组),采用聚合酶链反应-限制性片段长度多态性(PCR-RELP)方法检测CRP基因C+1444T多态性。结果:ACS组的CC、CT和TT基因型以及C等位基因频率分布与对照组无显著性差异(83.7%vs 86.7%、14.4%vs 12.3%、1.8%vs 1.1%和91.0%vs 92.8%,P值分别为0.292、0.439、0.540和0.243)。调整年龄、性别、吸烟、收缩压、舒张压、血糖和血脂等多因素后采用多元Logistic回归分析显示,CRP基因C+1444T多态性与ACS的发生仍无显著性关联(P>0.05)。结论:在中国苏皖地区汉族人群中,CRP基因C+1444T多态性与ACS的易感性无显著相关性。
Objective: To investigate the C + 1444T polymorphism of C-reactive portein (CRP) gene and susceptibility to acute coronary syndrome (ACS). Methods: Forty-three ACS patients (ACS group) and 285 coronary artery disease patients (coronary artery disease group) with coronary heart disease underwent coronary angiography during the same period from November 2003 to May 2008 were enrolled in this study. Polymerase chain reaction-restriction fragment length (PCR-RELP) was used to detect C + 1444T polymorphism of CRP gene. Results: The frequency of CC, CT and TT genotypes and C allele frequencies in ACS group were not significantly different from those in control group (83.7% vs 86.7%, 14.4% vs 12.3%, 1.8% vs 1.1% and 91.0% vs 92.8% , P values were 0.292, 0.439, 0.540 and 0.243, respectively). Multivariate logistic regression analysis showed that there was no significant correlation between C + 1444T polymorphism of CRP gene and occurrence of ACS (P> 0.05) after adjusting for multiple factors such as age, gender, smoking, systolic blood pressure, diastolic blood pressure, blood glucose and blood lipid. Conclusion: There is no significant correlation between C + 1444T polymorphism of CRP gene and the susceptibility of ACS among Chinese Han population in Jiangsu and Anhui provinces.