论文部分内容阅读
干扰素是由Issacs和Lindemann在1957年首先发现。早期临床应用的干扰素是从经过病毒刺激后的白细胞中提取,其产量低而且纯度小于1%。Schering公司应用DNA重组技术,把干扰素基因引入大肠杆菌,生产出大量纯度高达98%的人α-干扰素。随着其产量和质量问题逐步解决,α-干扰素已广泛试用于治疗白血病,特别是造血系统的恶性疾患。
Interferons were first discovered by Issacs and Lindemann in 1957. Early clinical application of interferon is extracted from virus-stimulated leukocytes with low yields and less than 1% purity. Schering Corporation uses DNA recombination technology to introduce the interferon gene into E. coli to produce large amounts of human interferon alpha up to 98% pure. As its production and quality problems are gradually resolved, alpha-interferon has been widely tested for the treatment of leukemias, especially malignancies of the hematopoietic system.