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目的:研究探讨经皮椎体成形术联合125I粒子植入治疗脊柱转移性肿瘤的临床疗效及安全性。方法:选取某医院收治的椎体成形术联合粒子125I植入治疗的45例脊柱转移性肿瘤患者。评价临床疗效。结果:该45例患者治疗顺利,疗效显著,未出现神经压迫以及神经损伤等症状。治疗后各项评分均较治疗前明显改善,Barthel指数以及VAS评分显著改善,差异具有统计学意义(P<0.05)。患者术后疼痛缓解指标显著改善,差异具有统计学意义(P<0.05)。且术后患者椎体前缘、中部高度丢失率均有明显改善。结论:经皮椎体成形手术联合125I粒子植入治疗脊柱转移性肿瘤能够迅速缓解由肿瘤导致的疼痛、并发症少、改善患者日常生活能力、大大提高患者的生活质量。
Objective: To study the clinical efficacy and safety of percutaneous vertebroplasty combined with 125I seed implantation in the treatment of spinal metastases. Methods: Forty-five patients with spine metastasis who underwent 125I implantation combined with vertebroplasty in a hospital were enrolled. Evaluation of clinical efficacy. Results: The 45 patients were successfully treated with significant curative effect. No symptoms such as nerve compression and nerve injury appeared. After treatment, all the scores were significantly improved than before treatment, Barthel index and VAS score improved significantly, the difference was statistically significant (P <0.05). Postoperative pain relief index was significantly improved, the difference was statistically significant (P <0.05). And postoperative patients with vertebral front, central height loss rate was significantly improved. CONCLUSION: Percutaneous vertebroplasty combined with 125I seed implantation in the treatment of spinal metastases can rapidly relieve pain caused by tumors, with fewer complications, improve patients’ daily living ability and greatly improve the quality of life of patients.