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目的探讨血清血管内皮细胞生长因子(VEGF)水平与鼻咽癌发生及淋巴结转移的关系。方法运用酶联免疫吸附测定法定量检测50例鼻咽癌患者(鼻咽癌组)、40例鼻咽部良性疾病患者(良性疾病组)和35例健康者(健康组)血清中的VEGF含量。并比较检测结果。结果鼻咽癌组患者血清中的VEGF表达水平[(425.43±239.56)ng/L]与良性疾病组[(140.36±108.67)ng/L]、健康组[(113.98±38.49)ng/L]比较,差异均有统计学意义(P<0.05);有淋巴结转移患者血清中的VEGF表达水平明显增高,差异有统计学意义(P<0.05)。结论血清VEGF水平检测可用于鼻咽癌的早期诊断,与鼻咽癌淋巴结转移相关。
Objective To investigate the relationship between the serum level of vascular endothelial growth factor (VEGF) and the occurrence of nasopharyngeal carcinoma and lymph node metastasis. Methods Serum levels of VEGF in 50 patients with nasopharyngeal carcinoma (nasopharyngeal carcinoma), 40 patients with benign nasopharyngeal diseases (benign disease group) and 35 healthy subjects (healthy group) were quantified by enzyme linked immunosorbent assay (ELISA) . And compare the test results. Results The serum level of VEGF in nasopharyngeal carcinoma patients [(425.43 ± 239.56) ng / L] was significantly higher than that in benign disease patients [(140.36 ± 108.67) ng / L] and healthy group [(113.98 ± 38.49) ng / L] (P <0.05). The expression of VEGF in serum of patients with lymph node metastasis was significantly increased (P <0.05), the difference was statistically significant (P <0.05). Conclusion The serum level of VEGF can be used for the early diagnosis of nasopharyngeal carcinoma and is related to lymph node metastasis of nasopharyngeal carcinoma.