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肺动脉高压(pulmonary arterial hypertension,PAH)患者使用肺血管扩张剂发生药物不良反应(adverse drug events,ADEs)很常见。ADEs可能导致生活质量下降;然而,它们与预后的关系未知。该研究的目的是确定开始皮下曲前列环素治疗后常见的ADEs是否与PAH的预后相关。方法:纳入来自4个PAH曲前列环素临床试验的受试者进行回顾性队列研究,其中
It is common for patients with pulmonary arterial hypertension (PAH) to develop adverse drug events (ADEs) using pulmonary vasodilators. ADEs may lead to a deterioration in quality of life; however, their relationship to prognosis is unknown. The purpose of this study was to determine whether common ADEs following the initiation of subcutaneous treprostinil treatment are associated with PAH prognosis. METHODS: A retrospective cohort study was conducted in subjects enrolled from 4 PAH Treprostinil clinical trials, of which