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目的 探讨HLA -DRB1 基因与2型糖尿病的关系。方法 应用PCR反向杂交法对18名2型糖尿病患者进行2型糖尿病与HLA -DRB1 基因的关联研究。结果 2型糖尿病患者HLA -DRB1 基因中HLA-DR7 基因频率明显高于对照组 (P<0.05)。 结论 2型糖尿病与HLA -DRB1 基因存在某些关联
Objective To investigate the relationship between HLA-DRB1 gene and type 2 diabetes. Methods The association between HLA-DRB1 and type 2 diabetes was studied in 18 type 2 diabetic patients by PCR reverse hybridization. Results The frequency of HLA-DR7 gene in HLA-DRB1 gene was significantly higher in type 2 diabetes mellitus than in control group (P <0.05). Conclusion There is some association between type 2 diabetes and HLA-DRB1 gene