论文部分内容阅读
妊娠期高血压疾病(HDCP)病因至今还不十分明确。目前认为HDCP的发病起源于胎盘的病理生理改变,此改变进一步导致全身血管内皮细胞损伤和功能异常,从而引起一系列HDCP的临床症状。这些病理改变是多种因素共同作用所致,包括遗传因素、免疫因素、胎盘或滋养叶细胞因素、基因蛋白表达异常、钙离子的作用、血管内皮损伤、凋亡甚至更多,相关分子生物学研究取得了许多成果。
The cause of HDCP is not yet clear. It is currently believed that the pathogenesis of HDCP originates from the pathophysiological changes of the placenta, and this change further leads to systemic vascular endothelial cell injury and dysfunction, causing a series of HDCP clinical symptoms. These pathological changes are caused by a combination of factors, including genetic factors, immune factors, placental or nodal cytokines, abnormal gene protein expression, the role of calcium ions, vascular endothelial injury, apoptosis and even more, related molecular biology Research has yielded many achievements.