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多数肾炎的发生与发展与体液免疫机制有关。一般认为,抗原抗体结合之后,激活补体,中性粒细胞游走,凝血系统的活化等对引起肾组织的损害都有重要的作用。免疫反应引起肾损害的部位与抗体有关。一种是肾小球基底膜(GBM)抗体或肾小管基底膜(TBM)抗体与肾组织结合引起病变;另一种是与肾组织无关的抗原抗体系统,例如,针对细菌、病毒或肾外组织的抗体在血液循环中结合成抗原抗体复合物(lmmune complexⅠc)沉积在肾内引起肾病变。上述两种情况尽管形成抗原抗体复合物时的部位不同,但是,免疫反应引起的肾损害部位都在肾小球基底膜和肾小管基底膜及其周围血管。
The occurrence and development of most nephritis and humoral immune mechanism. Is generally believed that antigen-antibody binding, activation of complement, neutrophil migration, activation of the coagulation system on the damage caused by renal tissue has an important role. Immune reaction caused by renal damage and antibody-related sites. One is a combination of glomerular basement membrane (GBM) antibodies or tuberular basement membrane (TBM) antibodies and kidney tissue causing lesions; the other is an antigen-antibody system unrelated to kidney tissue, for example, against bacteria, viruses, Tissue antibodies that bind to the lmmune complex Ic in the bloodstream deposit in the kidney and cause nephropathy. In both cases, although the site of formation of the antigen-antibody complex is different, the site of renal damage caused by the immune response is both the glomerular basement membrane and the tubular basement membrane and its surrounding blood vessels.