论文部分内容阅读
目的 :探讨肋骨和肺组织阻挡对高强度聚焦超声 (high intensityfocusedultrasound ,HIFU)破坏犬肝组织的影响。方法 :2 0条实验犬随机平均分为对照组和手术组 ,手术组模拟行肋骨部分切除、肋膈角闭合术 (partialcostectomyandcostophrenicangleclosure,PCCAC) ;以 0 .8MHz、焦距 12 0mm、定点点打、声功率 2 2 0W连续照射两组实验犬肝右叶 90s ,对肝毁损灶进行面积和体积测定及病理学检查。结果 :超声显示手术组犬肝形成 (1.0 4± 0 .2 3)cm2 回声增强区 ,对照组没有观察到回声增强区 ;肉眼下实验犬肝毁损灶体积 (3.2 4± 0 .4 7)cm3 ,与对照组具有显著性差异 (P<0 .0 5 ) ;对毁损灶的HE染色证实手术组犬肝毁损灶的坏死程度明显增强 ,范围增大。结论 :肋骨和含气肺组织的遮挡对HIFU破坏犬肝组织具有明显的负影响 ,行PCCAC后可以有效提高HIFU在肝脏治疗靶区内的有效能量 ,减少衰减
Objective: To investigate the effects of rib and lung tissue blockade on the canine liver tissue damaged by high intensity focused ultrasound (HIFU). Methods: Twenty dogs were randomly divided into control group and operation group. The operation group was performed partial ribotomy and partial capstelectomy (PCCAC). At 0. 8MHz, the focal length was 12 0mm, Power 2 220 W continuous irradiation of two groups of dogs canine right lobe 90s, liver damage area size and volume determination and pathological examination. Results: Echocardiography showed that the echogenic area of the canine liver was (1.04 ± 0.23) cm2 in the operation group, and no echogenic area was observed in the control group. The volume of canine liver lesions (3.2 4 ± 0.47) cm3 (P <0.05). HE staining of the lesion showed that the extent of necrosis of the liver lesion in the operation group was significantly increased and the range was increased. CONCLUSION: Blocking of rib and air-containing lung tissue has a significant negative impact on HIFU-disrupted canine liver tissue. PCCAC can effectively increase the effective energy of HIFU in liver target area and reduce the attenuation