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目的:了解侵袭性和惰性B细胞非霍奇金淋巴瘤(B-NHL)患者肝炎病毒感染的情况,比较两组患者肝炎病毒感染的差异。方法:回顾性分析本院1994年01月至2014年01月,733例初诊惰性B-NHL患者及同期148例侵袭性B-NHL患者肝炎病毒感染的资料,比较两组患者肝炎病毒感染的差异。结果:B-NHL患者抗丙型肝炎病毒抗体(HCV-Ab)阳性率为1.8%,其中侵袭性组及惰性组患者HCV-Ab阳性率分别为1.35%及1.9%。B-NHL组及惰性B-NHL组患者HCV-Ab阳性率均较全国一般人群明显升高(P<0.01),而侵袭性B-NHL组HCV-Ab阳性率较全国一般人群未见明显差异(P>0.05)。惰性组与侵袭性组相比较未见明显统计学差异(P>0.05)。B-NHL患者乙型肝炎病毒表面抗原(HBs-Ag)阳性率为9.0%,较全国一般人群明显增高(9.0%vs 7.2%)(P<0.05)。在B-NHL患者中,侵袭性组患者HBs-Ag阳性率较全国一般人群升高非常显著(14.2%vs 7.2%)(P<0.05),但惰性组患者HBs-Ag阳性率较全国一般人群未见明显统计学差异(7.9%vs 7.2%)(P>0.05)。惰性组与侵袭性组相比较,惰性组患者HBs-Ag阳性率明显低于侵袭性组(7.9%vs 14.2%,P=0.015)。在侵袭性B-NHL患者中乙肝“大三阳”者占4.7%,较惰性B-NHL组1.2%明显升高(4.7%vs 1.2%,P=0.004)。乙肝“小三阳”在两组患者间未见明显差异(5.5%vs 6.1%)(P>0.05)。结论:在B-NHL中HCV感染可能与惰性B-NHL关系更为密切而HBV感染可能与侵袭性B-NHL关系更为密切。
OBJECTIVE: To investigate the status of hepatitis virus infection in patients with invasive and non-B cell non-Hodgkin’s lymphoma (B-NHL) and to compare the differences in hepatitis virus infection between the two groups. Methods: The data of hepatitis virus infection in 733 newly diagnosed B-NHL patients and 148 patients with invasive B-NHL in our hospital from January 1994 to January 2014 were retrospectively analyzed. The differences of hepatitis virus infection between the two groups were compared . Results: The positive rate of HCV-Ab in patients with B-NHL was 1.8%. The positive rates of HCV-Ab in invasive group and inactive group were 1.35% and 1.9% respectively. The positive rates of HCV-Ab in patients with B-NHL and in patients with inactive B-NHL were significantly higher than those in the general population (P <0.01), while the positive rate of HCV-Ab in patients with aggressive B-NHL was not significantly different from that of the general population (P> 0.05). There was no significant difference between inert group and invasive group (P> 0.05). The positive rate of HBs-Ag in B-NHL patients was 9.0%, which was significantly higher than that in the general population in China (9.0% vs 7.2%) (P <0.05). Among B-NHL patients, the positive rate of HBs-Ag in aggressive patients was significantly higher than that of the general population (14.2% vs 7.2%) (P <0.05), but the positive rate of HBs-Ag in inactive patients was significantly higher than that of the general population No significant difference was found (7.9% vs 7.2%) (P> 0.05). Compared with the aggressive group, the positive rate of HBs-Ag in the inactive group was significantly lower than that in the aggressive group (7.9% vs 14.2%, P = 0.015). In patients with aggressive B-NHL, hepatitis B was significantly higher in 4.7% than in inactive B-NHL (4.7% vs 1.2%, P = 0.004). There was no significant difference between the two groups (5.5% vs 6.1%) (P> 0.05). CONCLUSIONS: HCV infection may be more closely linked to inactive B-NHL in B-NHL and HBV infection may be more closely related to invasive B-NHL.