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目的探讨蛋白琥珀酸铁和葡萄糖酸亚铁在早产儿和足月新生儿中的治疗效果。方法前瞻性研究将出现贫血的32例早产儿和98例足月新生儿随机分为蛋白琥珀酸铁组和葡萄糖酸亚铁组。两组分别给予蛋白琥珀酸铁和葡萄糖酸亚铁治疗14 d,比较各组的治疗效果,比较早产儿和足月新生儿的蛋白琥珀酸铁组间的治疗效果。结果在疗程结束后,早产儿蛋白琥珀酸铁组的血红蛋白,红细胞计数均高于葡萄糖酸亚铁组(P<0.05),网织红细胞疗程结束时变化明显升高(P<0.05)。足月儿蛋白琥珀酸铁组的血红蛋白、红细胞计数、红细胞平均体积均高于葡萄糖酸亚铁组(P<0.05),网织红细胞有明显变化趋势(P<0.05)。蛋白琥珀酸铁治疗的早产儿和足月儿中,足月儿组中的网织红细胞,红细胞平均体积明显高于早产儿组,且差异具有统计学意义(P<0.05)。结论在早产儿和足月新生儿中,与葡萄糖酸亚铁相比蛋白琥珀酸铁具有更好的治疗效果,且蛋白琥珀酸铁治疗足月新生儿时临床效果优于早产儿。
Objective To investigate the therapeutic effect of ferrous succinate and ferrous gluconate in preterm infants and full term neonates. METHODS: A prospective study of 32 preterm infants with anemia and 98 full-term newborns were randomized into the group of protein ferrous succinate and the group of ferrous gluconate. The two groups were given ferrous succinate and ferrous gluconate for 14 days. The therapeutic effect of each group was compared, and the treatment effect between the group of premature and full-term neonates was compared. Results At the end of treatment, the hemoglobin and erythrocyte counts in the protein ferric succinate group were higher than those in the ferrous gluconate group (P <0.05). The changes of reticulocyte in the pretreatment group were significantly increased (P <0.05). The hemoglobin, erythrocyte count and erythrocyte average volume of full-term infantile albumin succinate group were higher than that of ferrous gluconate group (P <0.05), and the reticulocyte changed obviously (P <0.05). Among the premature infants and full-term infants treated with protein succinate, the average volume of reticulocytes and erythrocytes in term infants was significantly higher than that of premature infants (P <0.05). Conclusions In preterm and term neonates, ferrous succinate has a better therapeutic effect than ferrous gluconate and the efficacy of ferrous succinate is better than that of premature infants in full-term neonates.