设计合成了一种新的用于生物素偶联的双功能螯合剂N--α(2-皮考基)-N-ε-D-生物素基-L-赖氨酸甲酯(PLB),并完成其Re(CO)3-PLB配合物的合成及化学结构的表征。[99Tcm(CO)3(H2O)3]+的标记条件研究表明,PLB配体浓度在10μmol/L以上,pH在正常生理值7.4左右,于95℃加热30 min,标记物的放化纯度大于95%,比活度达37~55.5 TBq/mmol。 A new bifunctional chelator N - α (2 - picoline) -N-ε-D-biotinyl L-lysine methyl ester (PLB) , And the synthesis of its Re (CO) 3-PLB complex and the characterization of its chemical structure were completed. The labeling conditions of [99Tcm (CO) 3 (H2O) 3] + showed that the concentration of PLB ligand was above 10μmol / L, the pH was at normal physiological value of about 7.4 and the temperature was raised at 95 ℃ for 30 min. 95%, specific activity of 37 ~ 55.5 TBq / mmol.