目的探索分析血清降钙素原(PCT)指导神经内科重症患者抗感染的临床价值。方法 82例神经内科重症患者,随机分为对照组及观察组,各41例。对照组患者由医生依据抗生素治疗指南进行抗感染治疗,观察组患者依据PCT检测水平决定抗感染治疗方案。对比两组患者的治疗效果。结果观察组患者有效率为85.4%,对照组患者有效率为80.5%,两组比较差异无统计学意义(P>0.05)。治疗前,两组患者的白细胞计数(WBC)、C反应蛋白(CRP)水平对比,差异均无统计学意义(P>0.05)。治疗后,两组患者WBC、CRP水平均低于本组治疗前,且观察组低于对照组,差异均具有统计学意义(P<0.05)。治疗后,观察组患者PCT水平低于本组治疗前,差异具有统计学意义(P<0.05)。观察组患者抗生素应用时间为(5.5±0.6)d,短于对照组的(9.2±1.7)d,差异具有统计学意义(t=13.142,P<0.05)。结论监测PCT对指导神经内科重症患者抗感染治疗具有重要的临床价值,兼备良好的有效性、安全性、可行性,值得推广。 Objective To explore the clinical value of serum procalcitonin (PCT) in guiding anti-infection in severe neurology patients. Methods 82 cases of severe neurology patients were randomly divided into control group and observation group, 41 cases each. Patients in the control group were treated with anti-infective therapy based on the antibiotic treatment guidelines. Patients in the observation group were given anti-infective treatment plans based on the PCT test levels. Compare the treatment effect of two groups of patients. Results The effective rate of observation group was 85.4%, while that of control group was 80.5%. There was no significant difference between the two groups (P> 0.05). Before treatment, there was no significant difference in WBC and C-reactive protein (CRP) between the two groups (P> 0.05). After treatment, the WBC and CRP levels in both groups were lower than those in the control group before treatment, and the observation group was lower than the control group, the differences were statistically significant (P <0.05). After treatment, the PCT level in the observation group was lower than that in the control group before treatment (P <0.05). The application time of antibiotics in observation group was (5.5 ± 0.6) d, shorter than that in control group (9.2 ± 1.7) d, the difference was statistically significant (t = 13.142, P <0.05). Conclusion Monitoring PCT has important clinical value in guiding the anti-infective treatment of severe patients in neurology department, and has good effectiveness, safety and feasibility and is worthy of promotion.