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目的检测鳞状细胞癌(squamous cell carcinoma,SCC)中的胃泌素释放肽受体(gastrin releasing peptide receptor,GRPR)探讨其与SCC分化程度的关系。方法用免疫组化(SP)法检测10例正常皮肤组织及46例不同分化程度SCC中GRPR的表达。结果 SCC组中33例(71.74%)阳性表达,正常皮肤组织中3例(30.00%)阳性表达,两组间GRPR的表达差异有统计学意义(P=0.022);高、中、低分化组中阳性表达分别为14例(70.00%)、9例(75.00%)、10例(71.43%),不同分化程度SCC组间GRPR的表达差异无统计学意义(P=0.916)。结论 GRPR在SCC及正常皮肤中均有表达,但在SCC中的表达高于正常皮肤,其表达与SCC的侵袭性无相关性。
Objective To detect the expression of gastrin releasing peptide receptor (GRPR) in squamous cell carcinoma (SCC) and investigate its relationship with the degree of SCC differentiation. Methods Immunohistochemistry (SP) was used to detect the expression of GRPR in 10 cases of normal skin tissue and 46 cases of SCC with different degree of differentiation. Results The positive expression of GRPR was found in 33 cases (71.74%) in SCC group and 3 cases (30.00%) in normal skin tissue. There was a significant difference in GRPR expression between the two groups (P = 0.022) There were 14 cases (70.00%), 9 cases (75.00%) and 10 cases (71.43%) respectively. There was no significant difference in the expression of GRPR between different differentiation SCC groups (P = 0.916). Conclusion GRPR is expressed in both SCC and normal skin, but its expression in SCC is higher than that in normal skin. The expression of GRPR has no correlation with the invasiveness of SCC.