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目的分析采取卡泊芬净治疗重症患者侵袭性真菌感染的临床效果。方法选取2012年2月~2013年2月中山市人民医院收治的重症患者80例,进行回顾性分析。结果患者确诊治疗总有效率、临床诊断有效率、拟诊有效率分别为73.33%、73.33%和50.00%,真菌清除率为25.00%,真菌替换率为5.56%。患者中共检出145株真菌,非白念珠菌中76株,白色念珠菌60株,烟曲霉菌96.21株(4.16%)。患者不良反应发生率为7.50%。结论卡泊芬净治疗重症患者侵袭性真菌感染,不良反应发生率低,值得临床推广应用。
Objective To analyze the clinical effect of caspofungin in the treatment of invasive fungal infections in critically ill patients. Methods Eighty critically ill patients admitted to Zhongshan People’s Hospital from February 2012 to February 2013 were retrospectively analyzed. Results The total effective rate of diagnosis and treatment, clinical diagnosis and effective rate were 73.33%, 73.33% and 50.00% respectively. The fungal clearance rate was 25.00% and the fungal replacement rate was 5.56%. A total of 145 strains of fungi were detected in the patients, 76 strains of non-Candida albicans, 60 strains of Candida albicans and 96.21 strains of Aspergillus fumigatus (4.16%). The incidence of adverse reactions in patients was 7.50%. Conclusion Caspofungin treatment of invasive fungal infections in critically ill patients, the incidence of adverse reactions is low, worthy of clinical application.