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肿瘤坏死因子α（ＴＮＦα）在同种器官移植排斥反应中起重要的作用。Ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ（Ｐｔｘ）是一种嘌呤类化合物，能够抑制ＴＮＦα的生物活性，并能减轻应用环孢素Ａ（ＣｓＡ）后所产生的毒性反应。本研究结果显示，单独应用Ｐｔｘ或与低剂量ＣｓＡ联合应用能够延长Ｃ３Ｈ／Ｈｅ小鼠同种（ＢＡＢＬ／ｃ）异位心脏移植物的存活时间，单独低剂量ＣｓＡ治疗（２ｍｇ／ｋｇ，共１２天）不能预防排斥反应的发生，可能与ＣｓＡ剂量太低有关。
Tumor necrosis factor alpha (TNFα) plays an important role in allograft rejection. Pentoxifylline (Ptx) is a purine compound that inhibits the biological activity of TNFα and reduces the toxic effects of cyclosporin A (CsA). The results of this study showed that Ptx alone or in combination with low-dose CsA could prolong the survival time of the same-type (BABL / c) ectopic heart allograft in C3H / He mice with low dose CsA alone (2mg / kg, 12 Day) can not prevent the occurrence of rejection, which may be related to the low dose of CsA.