论文部分内容阅读
明尼苏达大学Masonic癌症中心的最新研究表明,MYC,一个与高达20%癌症相关的关键致癌基因,和PVT1,一个非编码RNA的相互关系可能是理解MYC如何助长癌症细胞的关键.该研究发表在最新一期的Nature上.“我们知道MYC的扩增导致癌症.但我们同时也知道MYC并不单独扩增.它经常与邻近的染色体区域相配对.我们希望知道临近的基因是否具有作用.”身为主要作者,明尼苏达医学院生物科学院的助理教授Anindya Bagchi博士如此说.“我们冒险一试并吃惊地发现MYC与其邻居PVT1这出乎意外而非直观的相互
Recent research from the Masonic Cancer Center at the University of Minnesota suggests MYR, a key oncogene associated with up to 20% of cancers, and PVT1, a noncoding RNA, may be the key to understanding how MYC contributes to cancer cells. The first issue of Nature. ”“ We know that MYC amplification causes cancer, but we also know that MYC does not amplify alone, and it often matches with neighboring chromosomal regions. We want to know if nearby genes work. ”Said Anindya Bagchi, Ph.D., assistant professor at the College of Biological Sciences, Minnesota Medical School, as the lead author." We took a chance and were surprised to find that MYC and its neighbor PVT1 were unexpected and not intuitive