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目的探讨血红蛋白（Ｈｂ）对肝硬化大鼠血清一氧化氮（ＮＯ）含量及血流动力学的影响。方法应用５７Ｃｏ标记微球观察促红素长期治疗对肝硬化大鼠血流动力学参数的影响；应用荧光法测定大鼠血清ＮＯ含量。结果肝硬化大鼠全部出现高动力循环状态，且血清ＮＯ含量显著高于对照组、血Ｈｂ含量显著低于对照组；促红素治疗组，高动力循环状态明显改善，与未治疗组比较，Ｈｂ含量显著升高，血清ＮＯ含量显著降低。结论促红素致Ｈｂ增加，进而加速ＮＯ灭活对肝硬化高动力循环状态可能具有潜在治疗作用
Objective To investigate the effect of hemoglobin (Hb) on serum nitric oxide (NO) and hemodynamics in cirrhotic rats. Methods 57Co labeled microspheres were used to observe the effect of long-term erythropoietin treatment on hemodynamic parameters in cirrhotic rats. The serum NO level was measured by fluorescence method. Results All cirrhotic rats showed hyperdynamic circulatory state, and the content of serum NO was significantly higher than that of the control group. The content of blood Hb was significantly lower than that of the control group. The erythropoietin-treated group and the hyperdynamic circulation state were significantly improved. Compared with the untreated group, Hb content increased significantly, serum NO content decreased significantly. Conclusions Erythropoietin may increase Hb and accelerate NO inactivation, which may have a potential therapeutic effect on the hyperdynamic circulation of cirrhosis