心房颤动（AF）是临床最常见的快速型心律失常，AF患者面临较高的卒中与系统栓塞风险。AF能通过炎症反应、氧化应激、肾素-血管紧张素系统激活以及血流动力学变化等机制导致内皮功能障碍(ED)。多种内皮标记物与AF之间关系密切，ED对AF的发生、发展具有重要影响。本文旨在系统阐述AF与ED之间的关系。 Atrial fibrillation (AF) is the most common type of tachyarrhythmia in clinical practice. AF patients are at higher risk of stroke and systemic embolism. AF can lead to endothelial dysfunction (ED) through mechanisms such as inflammation, oxidative stress, renin-angiotensin system activation, and hemodynamic changes. A variety of endothelial markers and the close relationship between AF, ED on the occurrence and development of AF has an important impact. This article aims to systematically elaborate the relationship between AF and ED.