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目的:分析乌司他丁用于治疗脓毒症对患者肾功能及凝血功能的影响。方法:将60例SIRS患者随机分为治疗组和对照组,各30例,分别加用乌司他丁和采用常规综合治疗,比较两组临床治疗效果。结果:治疗组各项观察指标、凝血功能指标和血肌酐指标改善均优于对照组,肾功能损害所占比例(20.0%)低于对照组(46.7%),30 d生存率(90.0%)高于对照组(76.7%),比较差异显著(P<0.05)。结论:在常规综合治疗基础上加用乌司他丁,可有效改善SIRS患者凝血功能,减轻对肾功能的损害,具有较高的临床推广价值。
Objective: To analyze the effect of ulinastatin on renal function and coagulation function in patients with sepsis. Methods: Sixty patients with SIRS were randomly divided into treatment group and control group, with 30 cases in each group. Ulinastatin and conventional ulinastatin were used respectively to compare the clinical curative effect between the two groups. Results: The indexes of observation, coagulation index and serum creatinine in treatment group were better than those in control group. The proportion of renal dysfunction (20.0%) was lower than that of control group (46.7%), and the survival rate at 30 days was 90.0% Higher than the control group (76.7%), the difference was significant (P <0.05). Conclusion: Adding ulinastatin to conventional combined therapy can effectively improve the coagulation function and reduce the damage to renal function in patients with SIRS, which has a high clinical value.