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目的 研究表皮生长因子受体在髓母细胞瘤中的蛋白表达及基因水平的扩增情况,从而分析二者关系。方法 对48例髓母细胞瘤标本进行免疫组化染色,同时进行差异多聚酶链反应,放射自显影后根据其信号强弱来判断基因的扩增情况。结果48例髓母细胞瘤中有7例表皮生长因子受体呈阳性表达（14.58％）,其中成人6例,儿童1例;差异多聚酶链反应未显示表皮生长因子受体有基因水平的异常扩增。结论 表皮生长因子受体蛋白的过度表达存在于髓母细胞瘤,尤以成人为主,但其机制可能与基因的异常扩增无关。
Objective To study the expression of epidermal growth factor receptor (EGFR) in medulloblastoma and its gene amplification, and to analyze the relationship between them. Methods Forty - eight cases of medulloblastoma were immunohistochemically stained with differential polymerase chain reaction (PCR). After autoradiography, the amplification of the gene was judged according to its signal strength. Results Seven cases of 48 cases of medulloblastoma were positive for EGFR (14.58%), including 6 cases in adults and 1 case in children. Differential polymerase chain reaction did not show abnormal gene expression of epidermal growth factor receptor increase. Conclusion Epidermal growth factor receptor protein overexpression exists in medulloblastoma, especially in adults, but its mechanism may not be related to the abnormal amplification of genes.