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目的探讨影响重症急性胰腺炎(SAP)患者的死亡因素及治疗措施。方法回顾分析1993年1月至2006年6月死亡的24例SAP住院患者的病历资料,统计病死率的变化、影响因素和治疗措施。结果SAP患者总病死率为6.65%(24/361)。多器官功能衰竭(MODS)是SAP主要的早期死亡原因,感染是中后期死亡的重要原因。有合并症的SAP患者的死亡风险大于无合并症者。结论MODS是SAP主要的早期死亡原因。早期监护和支持治疗可有效降低SAP患者的早期病死率,中晚期应予个体化综合性治疗,在非手术治疗、介入治疗、手术治疗中选择适合患者的治疗方案,并应重视合并症的治疗。
Objective To investigate the death factors and treatment measures in patients with severe acute pancreatitis (SAP). Methods The data of medical records of 24 SAP inpatients who died from January 1993 to June 2006 were retrospectively analyzed. The changes of mortality, influencing factors and treatment measures were statistically analyzed. Results The overall mortality of patients with SAP was 6.65% (24/361). Multiple organ failure (MODS) is the major cause of early death in SAP, and infection is an important cause of death in the middle and late stages. SAP patients with comorbidities have a greater risk of dying than non-comorbid patients. Conclusion MODS is the main cause of SAP death. Early guardianship and supportive care can effectively reduce the early mortality of patients with SAP, should be individualized comprehensive treatment in the late, non-surgical treatment, interventional treatment, surgical treatment options for patients with treatment options, and should pay attention to the treatment of complications .