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人体端粒由富含鸟嘌呤(G)的DNA重复序列组成,该序列在一定条件下可以形成G-四链体DNA结构。小分子化合物诱导该结构的形成并使之稳定,可以抑制端粒酶活性而达到抗肿瘤的目的。因此,G-四链体DNA稳定剂的设计和筛选是近年来生物无机化学的重要前沿研究领域之一。在金属配合物中,钌配合物由于具有丰富的光化学、光物理特性以及生物活性,其作为G-四链体DNA稳定剂引起人们的高度关注。本文以近年一些代表性的研究工作为例,对钌配合物与G-四链体DNA相互作用方面的研究进展进行了综述。
Human telomeres consist of DNA-guanine-rich (G) repeat sequences that under certain conditions can form G-quadruplex DNA constructs. Small molecule compounds induce the formation of this structure and make it stable, which can inhibit the telomerase activity to achieve the purpose of anti-tumor. Therefore, the design and screening of G-quadruplex DNA stabilizers is one of the most important frontier research fields in bio-inorganic chemistry in recent years. Among metal complexes, ruthenium complexes have drawn great attention as G-quadruplex DNA stabilizers due to their abundant photochemical, photophysical and biological activities. In this paper, some representative research works in recent years are taken as an example to review the research progress on the interaction between ruthenium complexes and G-quadruplex DNA.