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目的分析老年原发性肾病综合征临床表现与病理特点,探讨有效的治疗方法。方法选择老年原发性肾病综合征患者120例,均行医技检查和肾活检,应用雷公藤多苷和泼尼松联合治疗,观察临床疗效并分析不同病理类型的用药疗效。结果治疗后,所有患者血清总胆固醇、三酰甘油、24h尿蛋白定量水平低于治疗前,血清白蛋白高于治疗前,差异有统计学意义(P<0.05)。治疗后总有效率为77.50%。各病理类型依总有效率由高到低依次为系膜增生性肾炎、微小病变、Lg A病变、膜性肾病、肾小球硬化症。结论雷公藤多苷和泼尼松治疗老年原发性肾病综合征效果较好,但不同病理类型间疗效有差异。
Objective To analyze the clinical features and pathological features of elderly patients with primary nephrotic syndrome and to explore effective treatment methods. Methods A total of 120 elderly patients with primary nephrotic syndrome were enrolled in this study. Both medical examination and renal biopsy were performed. The combination of tripterygium glycosides and prednisone was used to observe the clinical effect and analyze the curative effect of different pathological types. Results After treatment, the levels of serum total cholesterol, triglyceride, and 24-hour urinary protein in all patients were lower than those before treatment, and serum albumin was higher than before treatment (P <0.05). After treatment, the total effective rate was 77.50%. According to the total effective rate of all pathological types from high to low mesangial proliferative glomerulonephritis, minimal change, Lg A disease, membranous nephropathy, glomerulosclerosis. Conclusion Tripterygium glycosides and prednisone treatment of elderly patients with primary nephrotic syndrome is better, but the efficacy of different pathological types are different.