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目的:探讨依拉普利联合中药对高血压病合并高脂血症患者血液流变学的影响,为临床用药提供客观依据。方法:选取96例原发性高血压病合并高脂血症患者为研究对象,采用随机分组法分为对照组和治疗组。其中对照组48例予常规治疗+依拉普利,治疗组48例在对照组基础上加用中药治疗,治疗15 d后,观察并记录两组治疗前后血沉(ES)和血脂成分的变化。结果:两组治疗前ES比较,差异无统计学意义(P>0.05);治疗后治疗组ES明显低于对照组,差异有统计学意义(P<0.05)。治疗前两组血脂成分比较,差异均无统计学意义(P>0.05);治疗后治疗组血脂中TC、TG、LDL-C的含量明显低于对照组,而治疗组中HDLC的含量明显高于对照组,两组比较,差异均有统计学意义(P<0.05)。结论:依拉普利联合中药治疗高血压病合并高脂血症,能更有效降低患者的血脂含量及血沉。
Objective: To investigate the effects of enalapril combined with traditional Chinese medicine on hemorheology in patients with hypertension and hyperlipidemia, and to provide objective evidence for clinical use. Methods: Ninety-six patients with essential hypertension complicated with hyperlipidemia were selected as study subjects and divided into control group and treatment group by random grouping method. In the control group, 48 cases were treated with conventional therapy and enalapril. The treatment group was treated with traditional Chinese medicine on the basis of the control group. After 15 days of treatment, the changes of ESR and blood lipid components were observed and recorded before and after treatment. Results: There was no significant difference in ES between the two groups before treatment (P> 0.05). After treatment, the ES of the treatment group was significantly lower than that of the control group (P <0.05). The levels of TC, TG and LDL-C in the blood lipid of the treatment group were significantly lower than those of the control group after treatment, while the content of HDLC in the treatment group was significantly higher In the control group, the differences between the two groups were statistically significant (P <0.05). Conclusion: The combination of Chinese medicine and laprep in the treatment of hypertension complicated with hyperlipidemia can reduce the blood lipid level and erythrocyte sedimentation rate more effectively.