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在卵类粘蛋白柱上 ,考察了酮洛芬对映体在 3种流动相体系下的保留行为 ,建立了同时分离酮洛芬及其甲酯两对对映体的较佳色谱条件。方法可用于酶法立体选择性水解或酯化过程中生成的 4种化合物的同时测定
The retention behavior of ketoprofen enantiomers under three mobile phase systems was investigated on egg mucin column, and the best chromatographic conditions for the simultaneous separation of two enantiomers of ketoprofen and its methyl ester were established. The method can be used for the simultaneous determination of four compounds generated during enzymatic stereoselective hydrolysis or esterification