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交感神经、儿茶酚胺类神经递质和免疫细胞膜表面的各型肾上腺素能受体与慢性心理应激性免疫抑制的产生、发展密切相关。慢性心理应激下 ,蓝斑和下丘脑腹正中核等脑区发出的信号可使交感神经兴奋 ,导致儿茶酚胺类神经递质的释放 ,并引起信号在细胞内进一步转导 ,这对免疫细胞的成熟、分化、增殖 ,激活以及转运等可产生重要的抑制性调节作用。
Sympathetic nerve, catecholamine neurotransmitter and immune cell membrane surface of adrenergic receptors and chronic psychological stress immunosuppression is closely related to the development. Chronic psychological stress, the blue plaque and the hypothalamic abdomen and other nucleus of the brain issued a signal that can sympathetic excitement, leading to the release of catecholamine neurotransmitters and cause further signal transduction in the cell, which is immune cells Mature, differentiation, proliferation, activation and transport can have an important inhibitory regulatory role.