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本文用放射免疫法对慢性浅表性胃炎39例,慢性萎缩性胃炎45例、胃溃疡17例,十二指肠溃疡18例、胃癌8例和正常人32例同时测定了血液、胃液、胃窦和十二指肠粘膜的胃泌素浓度(分别简称SGC、GJGC、AGC、DGC)。结果表明,SGC和GJGC在各组内个体差异很大。各疾病组与正常对照组之间均无显著性差异。慢性萎缩性胃炎患者的AGC低于正常对照组,其降低程度与胃粘膜萎缩程度有关。除萎缩性胃炎外其它各疾病组的DGC和DGC/AGC均显著高于正常对照组。胃溃疡和胃癌患者中胃体部病变时各种胃泌素浓度均呈高于胃窦部病变的趋势。十二指肠溃疡患者DGC与SGC间呈明显的相关关系(r=0.75、P<0.001).本文讨论了各种常见上胃肠道疾病时各部胃泌素的变化及其意义。
In this article, 39 cases of chronic superficial gastritis, 45 cases of chronic atrophic gastritis, 17 cases of gastric ulcer, 18 cases of duodenal ulcer, 8 cases of gastric cancer, and 32 cases of normal subjects were measured for blood, gastric juice and stomach by radioimmunoassay. Gastrin concentrations in the antrum and duodenal mucosa (SGC, GJGC, AGC, DGC, respectively). The results show that there are large individual differences between SGC and GJGC in each group. There was no significant difference between each disease group and normal control group. The AGC of patients with chronic atrophic gastritis was lower than the normal control group, and the degree of reduction was related to the degree of gastric mucosal atrophy. In addition to atrophic gastritis, DGC and DGC/AGC were significantly higher in the other disease groups than in the normal control group. The gastrin concentrations in gastric body lesions in patients with gastric ulcer and gastric cancer were higher than those in gastric antrum. There was a significant correlation between DGC and SGC in patients with duodenal ulcer (r=0.75, P<0.001). This article discussed the changes of gastrin in various parts of common gastrointestinal diseases and their significance.