考察了抗白内障药双硫伦乳剂中双硫伦的化学稳定性 ,测定了不同的乳剂组成对双硫伦化学稳定性的影响 ,得出双硫伦降解服从一级反应 ,速率常数与温度关系符合阿累尼乌斯方程 ,其中较好的处方中双硫伦于 4℃时的降解速度常数为 1 516× 10 -4·d-1 ,活化能为 153 2kJ·mol-1 ,t0 9,4℃为 695 2d The chemical stability of bisulfan in anti-cataract drug was investigated. The effects of different emulsion compositions on the chemical stability of bisulfan were investigated. The results showed that the degradation of bisulfan led the first order reaction and the relationship between the rate constant and temperature According to the Arrhenius equation, the degradation rate constant of cefalene at 4 ℃ is 1 516 × 10 -4 · d -1, the activation energy is 153 2kJ · mol -1, t 0 9, 4 ° C 695 2d