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庆大霉素的用药剂量,给药途径和间隔时间,国内方案很多,各不相同。本文作者根据药物动力学原理对庆大霉素进行了血药浓度的计算,以探讨其最佳给药方案。其具体意见如下: 1.目前我国大部分地区,使用剂量似乎有些偏低,采用每次80mg,1天2次,肌肉注射,其间隔时间为6～8小时,最低血药浓度分别为0.038μg/ml、0.065μg/ml。有的单位采用每次40mg,1天2次,肌注。这样,血药浓度就更低,不仅达不到治疗目的,反而使细菌易产生耐药性。2.静脉滴注给药每次300mg,4～5小时滴完,血药浓度分别为13.99μg/ml;12.42μg/ml,按一般血药浓度控制在10μg/ml以下的要求,有些偏高,似应减慢滴注速度,以防产生毒性反应。3.肾功能正常的成年人(老年人除外),肌内注
Gentamycin dosage, route of administration and interval time, many domestic programs, different. According to the principle of pharmacokinetics, the author calculated the concentration of gentamycin in order to find out the optimal dosage regimen. The specific comments are as follows: 1. At present, most of China’s use of the dose seems to be somewhat low, with each 80mg, 1 day 2 times, intramuscular injection, the interval of 6 to 8 hours, the minimum plasma concentrations were 0.038μg / ml, 0.065 μg / ml. Some units use each 40mg, 1 day 2 times, intramuscular injection. In this way, lower blood concentration, not only fail to achieve the purpose of treatment, but to make bacteria prone to drug resistance. 2. intravenous infusion of 300mg each time, 4 to 5 hours drops finished, plasma concentrations were 13.99μg / ml; 12.42μg / ml, according to the general blood concentration control in the 10μg / ml the following requirements, some high , It seems to slow infusion rate, to prevent toxic reactions. 3. Normal renal function of adults (except for the elderly), intramuscular injection