耐甲氧西林金黄色葡萄球菌可以引起人类的感染,对有效治疗也构成了威胁,日益成为临床[1]、实验室、感染控制[2]和卫生政策决策领域[3]关注的焦点。1940年青霉素引入临床,金黄色葡萄球菌[4]几乎全部敏感。但耐药很快出现,因为该菌产生了质粒介导的β-内酰胺酶(今天,超过95%的临 Methicillin-resistant Staphylococcus aureus can cause human infections and poses a threat to effective treatment and is increasingly becoming a focus of attention in clinical [1], laboratories, infection control [2] and health policy decision-making [3]. Penicillin was introduced into the clinic in 1940, and Staphylococcus aureus [4] was almost entirely sensitized. However, resistance is rapidly emerging as the bacteria produce plasmid-mediated beta-lactamase (more than 95%