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目的通过对2013年-2014年广西地区42 525例新生儿葡萄糖-6-磷酸脱氢酶(G6PD)筛查及召回确诊数据分析,了解广西地区G6PD缺乏情况。方法取出生72h后新生儿足跟末梢血3滴于滤纸血片上,应用荧光法对新生儿进行G6PD缺陷筛查,阳性病例用G6PD/6PGD比值法确诊。结果 42 525例新生儿中,G6PD缺乏人数为3136例,初筛阳性率为7.4%,其中男性为2528例,发病率为10.9%,女性为601例,发病率为3.1%。召回用G6PD/6PGD比值法进行确诊的361例新生儿中,有337例确诊为G6PD缺乏症患儿,并有24例结果转为阴性。结论广西地区是G6PD缺乏的高发地区,男性患者明显多于女性(P<0.01)。
Objective To investigate the G6PD screening and recalled data from 42 525 newborns in Guangxi from 2013 to 2014 so as to understand the lack of G6PD in Guangxi. Methods The neonatal hemorrhagic hemorrhagic hemorrhagic fever was removed 3 days after the raw blood was taken from the filter paper. The neonatal G6PD deficiency was screened by fluorescence method. The positive cases were diagnosed by G6PD / 6PGD ratio method. Results Among 42 525 newborns, the number of G6PD deficiency was 3136 and the positive rate of primary screening was 7.4%, of which 2528 were male, the incidence was 10.9% and the female was 601, the incidence was 3.1%. Of the 361 newborns who recalled G6PD / 6PGD odds ratios, 337 were diagnosed with G6PD deficiency and 24 were negative. Conclusion Guangxi is a high incidence of G6PD deficiency, with significantly more males than females (P <0.01).