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目的 :探讨肿瘤坏死因子 (TNF -α)在人膜增生性肾小球肾炎发病中的作用。方法 :采用病理组织学及免疫组织化学SABC法对 2 0例人膜增生性肾小球肾炎进行染色观察。结果 :TNF -α蛋白在肾组织内表达增加 ,阳性反应见于肾小管上皮细胞和肾小球内 ,以肾近曲小管上皮细胞阳性最明显 ,与正常组相比有显著性差异 (P <0 .0 1) ,肾小球内呈程度不等的弱阳性 ,但与正常组相比无显著性差异 (P >0 .0 5 ) ,远曲小管阳性反应不明显。结论 :TNF -α在肾小管内表达增强可能在肾脏纤维化及硬化中起重要的介导作用
Objective: To investigate the role of tumor necrosis factor (TNF-α) in the pathogenesis of human membranous proliferative glomerulonephritis. Methods: Twenty cases of proliferative glomerulonephritis of human membrane were stained with histopathology and immunohistochemical SABC method. Results: The expression of TNF-α protein was increased in renal tissues. The positive reaction was found in renal tubular epithelial cells and glomerulus. The positive expression of TNF-α protein in renal proximal tubule epithelial cells was the most significant difference compared with normal group (P <0 .0 1), the degree of glomerular within a weak positive, but no significant difference compared with the normal group (P> 0.05), distal tubule positive reaction was not obvious. CONCLUSIONS: The increased expression of TNF-α in renal tubules may play an important mediating role in renal fibrosis and sclerosis