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AIM: To retrospectively assess the effect of comprehensive cryosurgery (ablation of intraand extra-hepatic tumors) plus dendritic cell-cytokine-induced killer cell immunotherapy in metastatic hepatocellular cancer. METHODS: We divided 45 patients into cryo-immunotherapy (21 patients), cryotherapy (n = 12), immunotherapy (n = 5) and untreated (n = 7) groups. Overall survival (OS) after diagnosis of metastatic hepatocellular cancer was assessed after an 8-year follow-up. RESULTS: Median OS was higher following cryo-immu-notherapy (32 mo) or cryotherapy (17.5 mo; P < 0.05) than in the untreated group (3 mo) and was higher in the cryo-immunotherapy group than in the cryotherapy group (P < 0.05). In the cryo-immunotherapy group, median OS was higher after multiple treatments (36.5 mo) than after a single treatment (21 mo; P < 0.05). CONCLUSION: Cryotherapy and, especially, cryoimmunotherapy significantly increased OS in metastatic hepatocellular cancer patients. Multiple cryo-immunotherapy was associated with a better prognosis than single cryo-immunotherapy.
METHODS: We divided 45 patients into cryo-immunotherapy Overall survival (OS) after diagnosis of metastatic hepatocellular cancer was evaluated after an 8-year follow-up. RESULTS: Median OS was higher than (n = 5) and untreated cryo-immu-notherapy (32 mo) or cryotherapy (17.5 mo; P <0.05) than in the untreated group (3 mo) and was higher in the cryo-immunotherapy group than in the cryotherapy group cryoimmunotherapy group, median OS was higher after multiple treatments (36.5 mo) than after single treatment (21 mo; P <0.05). CONCLUSION: Cryotherapy and, especially, cryoimmunotherapy increased significantly in OS in metastatic hepatocellular cancer patients. immunotherapy was associated with a better prognosis than single cryo-immunotherapy.