目的探讨西药房实施退药干预前、后的差异,并分析其临床价值。方法选择我院西药房实施退药干预前、后各580000张处方为研究对象,通过分析其中退药处方的原因并实施针对性的退药干预措施,比较干预前后的退药处方差异。结果西药房实施退药干预后,退药处方的数量减少为683张,明显低于干预前的1270张,退药处方占总处方比例在干预后为0.118%,明显低于退药干预前的0.219%,差异具有统计学意义(P<0.05);退药处方中由于不良反应、禁忌证造成的处方数量较大,但占总退药处方的比例较干预前有明显降低;而由于医保、经济因素、医嘱修改造成的处方比例明显升高。结论西药房实施退药干预措施,可以有效减少退药处方数,尤其是由于人为因素、主观因素造成的退药处方数可显著降低,退药干预在西药房的实际临床运用中具有重要价值。 Objective To explore the differences of western medicine pharmacy before and after the implementation of withdrawal medicine and to analyze its clinical value. Methods Five hundred and fifty thousand prescriptions were collected before and after the withdrawal of drug intervention in western pharmacy of our hospital. The prescriptions of withdrawal prescription were analyzed and the targeted withdrawal interventions were implemented. The differences of prescriptions before and after intervention were compared. Results After the withdrawal of western medicine pharmacy, the number of retreated prescriptions decreased to 683, significantly lower than 1270 pre-interventions. The proportion of retreated prescriptions in total prescriptions after intervention was 0.118%, which was significantly lower than that before retreatment intervention 0.219% respectively. There were significant differences between the two groups (P <0.05). Because of adverse reactions and contraindications, the number of prescriptions in retreated prescriptions was larger than that in pre-intervention prescriptions. However, due to medical insurance, Economic factors, prescriptions caused by prescription changes significantly increased. Conclusion The western medicine pharmacy can effectively reduce the number of prescriptions for retreat, especially because of human factors and subjective factors, which can significantly reduce the number of retreat prescriptions. The withdrawal intervention is of great value in the actual clinical application of western pharmacy.