严重创伤以早期过度激活的炎症反应及随后的T细胞功能下降(免疫抑制)、对感染的易感性增加、脓毒症和多器官功能衰竭(MOF)为特征。在早期的全身炎症反应综合征(SIRS)期和后期的代偿性抗炎反应综合征(CARS)期,病人极易遭受二重打击,从而激发脓毒症、MOF和死亡的病理生理。对严重 Severe trauma is characterized by an early over-activated inflammatory response followed by a decrease in T-cell function (immunosuppression), an increased susceptibility to infection, sepsis and multiple organ failure (MOF). In patients with early systemic inflammatory response syndrome (SIRS) and later compensatory anti-inflammatory response syndrome (CARS), patients are extremely vulnerable to double strikes, triggering sepsis, MOF, and the pathophysiology of death. Serious