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目的:建立一种用非水滴定法来测定丹参素钠原料药的含量测定方法。方法:将丹参素钠用冰醋酸-醋酐(1∶1.5)溶解后,以结晶紫为指示液,用高氯酸滴定液(0.1 mol.L-1)滴定,用电位法来判定滴定终点,并用指示剂在电位突跃时的颜色作为滴定终点颜色;结果:非水滴定法用来测定丹参素钠原料含量,与传统高效液相法相比较,二者结果相吻合。结论:该方法操作简便、精密度高,可作为丹参素钠原料药含量测定的方法。
Objective: To establish a non-aqueous titration method for the determination of Danshensu sodium API assay. Methods: After the sodium danshensu was dissolved in glacial acetic acid-acetic anhydride (1: 1.5), the solution was titrated with crystal violet as indicator solution and perchloric acid titration solution (0.1 mol·L-1) And the color of the indicator when the potential jumps is used as the endpoint color of the titration. Results: The non-aqueous titration method was used to determine the content of sodium danshensu, which was in good agreement with the traditional HPLC method. Conclusion: The method is simple, high precision, and can be used as a method for the determination of Danshensu sodium API.