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目的 :探讨硒对新生儿神经行为发育和甲状腺功能调节的作用。方法 :采用 Ebselen对围产期铅暴露进行干预流调 ,测定脐血铅、血硒及促甲状腺素、活性甲状腺素 ,在新生儿出生后 d2 6～ 2 8采用双盲法进行神经行为发育 (NBNA)评价。结果 :干预组脐血铅均值为 0 .34μmol/L,显著低于对照组的 0 .5 μmol/L,血硒、血锌、GSH- Px均高于对照组 (P<0 .0 1) ,TT3、、TT3/TT4 比值、FT3/FT4 比值均高于对照组。结论 :采用硒干预对降低新生儿铅毒 ,改善微量营养素 ,提升抗氧化功能 ,改善甲状腺功能代谢 ,保护新生儿智力正常发育有明显促进作用。
Objective: To investigate the effect of selenium on neurobehavioral development and thyroid function regulation in neonates. Methods: Ebselen was used to intervene the flow of perinatal lead exposure. Cord blood lead, blood selenium and thyroid stimulating hormone and active thyroid hormone were measured. After neonatal d2 6 ~ 2 8, the neurobehavioral development NBNA) evaluation. Results: The average cord blood lead level was 0.34 μmol / L in intervention group, which was significantly lower than 0.5 μmol / L in control group, and selenium, blood zinc and GSH- Px in control group were significantly higher than those in control group (P <0.01) , TT3, TT3 / TT4 ratio, FT3 / FT4 ratio were higher than the control group. Conclusion: The intervention of selenium can significantly reduce neonatal lead poisoning, improve micronutrients, enhance anti-oxidant function, improve thyroid functional metabolism and protect the normal intelligence development of neonates.