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抗菌素滴眼剂一般是采用无菌操作制备。尽管如此,往往由于无菌操作不严格,包装容器处理不当,以及使用过程中被污染,而致细菌滋生。为了防止滴眼剂中细菌的滋生,可加入抑菌剂。一般常用而认为有效者有三氯叔丁醇、苯乙醇、氯甲酚、硫柳汞、氯化苯甲烃铵(洁尔灭)、尼泊金类和氧氰化汞等。但对各种抑菌剂的评价,由于试验条件和使用的客体的不同,文献中的记载颇不一致,对于有效浓度亦有不同见解。McCullogh、Theodore、Klein及John等认
Antimicrobial eye drops are generally prepared using aseptic procedures. Nonetheless, bacterial growth is often caused by inadequate aseptic handling, improper handling of packaging containers, and contamination during use. In order to prevent the growth of bacteria in eye drops, antibacterial agents can be added. Commonly used and considered effective persons are chlorobutanol, phenylethyl alcohol, chlorocresol, thimerosal, benzalkonium chloride (benzalkonium bromide), nipagin and mercuric cyanogen and so on. However, the evaluation of various bacteriostats, due to different test conditions and the use of the object, the literature is quite inconsistent, the effective concentration is also different views. McCullogh, Theodore, Klein and John and so recognized