宫腔粘连分离术后不同预防宫腔粘连方法的疗效及生殖预后研究

来源 :南京医科大学学报(自然科学版) | 被引量 : 0次 | 上传用户:lili_mine12_5
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目的:探索较为有效预防宫腔粘连分离术后宫腔再粘连及复原生殖功能的方法。方法:选择2011年9月~2013年3月民权县中医院接受治疗的116例宫腔粘连患者为研究对象。随机将其中72例分为实验组,采用Foley球囊管预防粘连;余者44例分为对照组,采用节育器预防粘连。以术后子宫内膜厚度、妊娠时间、宫腔再粘连、慢性子宫内膜炎、内膜形态学分型、妊娠及自然流产情况为观察指标。结果:术后3个月,实验组患者有效率为95.8%,对照组为79.5%;实验组宫腔再粘连率为4.2%,显著低于对照组的20.5%(P<0.05);实验组慢性子宫内膜炎发生率为2.8%,显著低于对照组的18.2%(P<0.05);实验组形态学分型Ⅰ型者构成比为61.1%,显著高于对照组的27.3%(P<0.05);实验组平均内膜厚度为(9.3±0.5)mm,显著高于对照组的(8.2±0.9)mm(P<0.05);实验组术后平均妊娠时间为(4.6±1.0)个月,显著低于对照组的(5.2±0.8)个月(P<0.05)。两组患者术后妊娠率无显著差异性(P>0.05);而实验组患者术后自然流产率为14.3%,显著低于对照组的45.5%(P<0.05)。结论:相对于传统方案,Foley球囊管扩张术更具有效预防术后宫腔再粘连作用,且能有效复原宫腔生殖功能,降低不良孕产发生率。 Objective: To explore a more effective prevention of uterine cavity adhesions and re-adhesion and reproductive function of the method. Methods: One hundred and sixteen patients with intrauterine adhesions undergoing treatment at Minquan County Chinese Medicine Hospital from September 2011 to March 2013 were selected as the study subjects. 72 cases were randomly divided into experimental group, the use of Foley balloon catheter to prevent adhesion; the remaining 44 cases were divided into control group, the use of IUDs prevent adhesions. Postoperative endometrial thickness, gestational age, intrauterine adhesions, chronic endometritis, endometrial morphology, pregnancy and spontaneous abortion were observed. Results: At 3 months after operation, the effective rate was 95.8% in the experimental group and 79.5% in the control group. The re-adhesion rate in the experimental group was 4.2%, which was significantly lower than that in the control group (20.5%, P <0.05) The incidence of chronic endometritis was 2.8%, which was significantly lower than that of the control group (18.2%, P <0.05). The percentage of morphological type Ⅰ in the experimental group was 61.1%, significantly higher than that in the control group (27.3%, P < 0.05). The mean intimal thickness in the experimental group was (9.3 ± 0.5) mm, which was significantly higher than that in the control group (8.2 ± 0.9) mm (P <0.05). The mean postoperative mean pregnancy time in the experimental group was (4.6 ± 1.0) , Which was significantly lower than that in the control group (5.2 ± 0.8) months (P <0.05). There was no significant difference in postoperative pregnancy rate between the two groups (P> 0.05). The spontaneous abortion rate in the experimental group was 14.3%, which was significantly lower than that in the control group (45.5%, P <0.05). Conclusion: Compared with the traditional protocol, Foley balloon dilatation is more effective in preventing postoperative uterine adhesions, and can effectively restore uterine reproductive function and reduce the incidence of adverse pregnancy.
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