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目的:初步探讨KCTD10基因在上皮型脑膜瘤中的表达及意义。方法:收集正常脑膜及新鲜上皮型脑膜瘤标本7例,用免疫组化染色法检测KCTD10在这些标本中的表达情况。结果:在3例正常脑膜中未检测到KCTD10的表达,在所有上皮型脑膜瘤(WHOⅠ级)组织中均检测到KCTD10的高表达。结论:KCTD10在上皮型脑膜瘤中表达水平高,提示KCTD10可能在上皮型脑膜瘤的发生发展中起作用。
Objective: To investigate the expression and significance of KCTD10 gene in epithelial meningiomas. Methods: Totally 7 cases of normal meningioma and fresh epithelial meningiomas were collected. The expression of KCTD10 in these samples was detected by immunohistochemical staining. Results: No expression of KCTD10 was detected in 3 normal meninges, and high expression of KCTD10 was detected in all epithelial meningiomas (WHO grade Ⅰ). Conclusion: The high expression of KCTD10 in epithelial meningiomas suggests that KCTD10 may play a role in the development of epithelial meningioma.