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1半胱天冬酶半胱天冬酶(Caspase)是一个半胱氨酸蛋白酶家族,这个家族的所有成员在它们的活性位点均有半胱氨酸,并且切割靶蛋白也均在特异性的天门冬氨酸位点后,因此称半胱天冬酶[1]。它们在细胞凋亡的过程中起着关键性作用。目前,该家族有14个成员被克隆出[2],在氨基酸序列、结构及酶的特性上均相似。根据在级联反应上下游的位置及功能的不同,可分为3大类。第
Caspases are a family of cysteine proteases in which all members of this family have cysteines at their active site and also cleave the target protein in a specific After the aspartate site, so called caspase [1]. They play a key role in the process of apoptosis. At present, 14 members of this family have been cloned [2] and are similar in amino acid sequence, structure and enzymatic properties. According to the cascade reaction in the lower reaches of the location and function of different, can be divided into three categories. No.